with the Beta-Lactamase
inhibitor clavulanic acid proved a highly effective answer to the dual problems of emerging penicillin resistance and increased mixed infection. A solution for all these problems was in the hands of fervent physicians in the year 1981.
and clavulanate combination kept the activity of amoxicillin against streptococci, including pneumococci, but restored the activity of amoxicillin against Beta-Lactamase
producing organisms, such as staphylococci, Escherichia coli and Haemophilus influenzae, and extended its activity against klebsiella and Bacteroides fragilis infections”.